Health

New mothers’ placenta could help reduce brain injury in other





The placenta from mothers of healthy newborns could one day be used to reduce brain injury in growth-restricted babies, according to University of Queensland research.

Dr Julie Wixey from UQ’s Centre for Clinical Research said the study found stem cells sourced from a healthy placenta may reduce damaging inflammation in these babies after only three days.

There is currently no treatment to protect the brains of a growth-restricted baby.

Up to 50 per cent of them have long term issues ranging from mild learning and behavioral disorders all the way through to cerebral palsy.

We know there’s inflammation in the brain and it doesn’t cease once these babies are born.

Our study has shown we could reduce inflammation and ongoing brain injury by treating these newborns on the day they’re born using a combination of two types of stem cells – endothelial colony forming cells and mesenchymal stromal cells – isolated from a healthy human placenta.”

Dr Julie Wixey, UQ’s Centre for Clinical Research

About 32 million growth-restricted babies are born around the world each year, with around 10 per cent of newborns in Australia affected.

These babies fail to grow normally in the womb, often because they haven’t received enough nutrients and oxygen from the placenta.

“Our research has found after just three days, the combination stem cell therapy not only reduced inflammation but also, importantly, appeared to repair damaged blood vessels in the brain in animal models,” Dr Wixey said.

“We’re really excited by the outcomes of this study and we hope it’ll improve these babies’ lives long term.”

The patent technique for harvesting stem cells from the placenta was co-invented by UQ’s Professor Kiarash Khosrotehrani and Dr Jatin Patel – now at the Queensland University of Technology (QUT).

“This has been a fantastic collaborative study and demonstrates the exciting potential of stem cell therapy in the near future in treating unwell babies,” Dr Patel said.

“We are now working towards scaling up our patented stem cell technology, that will result in greater quantities of cells to drive and expand the preclinical animal studies with the aim of progressing towards a human trial.”

The researchers will now investigate the longer-term outcomes of the combination stem cell treatment.

Source:

The University of Queensland

Journal reference:

Chand, K.K., et al. (2021) Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn. npj Regenerative Medicine. doi.org/10.1038/s41536-021-00185-5.

Read The Full Article Here

Unraveling Hikikomori: A Global Phenomenon of Social Withdrawal
The Lasting Impact of Sibling and Family Comparisons on Childhood and Adulthood
Overcoming the Inferiority Complex Among College Students
Barbie: Breaking Stereotypes and Embracing Creativity
The Mysteries of Extended Breastfeeding: From Family Irritation to Mother-to-Mother Comparisons
Prince Harry Opens Up About When He Knew Meghan Markle
Rich Pregnant vs Broke Pregnant
How To Watch The Perseid Meteor Shower With Your Family
Baby Care Tips
How to Care a newborn kitten
Main Tota Hare Rang Ka
Drug Free Kids
The Oedipus Complex: Understanding its Dynamics, Development, and Potential Disruptions
The Lasting Impact of Sibling and Family Comparisons on Childhood and Adulthood
Barbie: Breaking Stereotypes and Embracing Creativity
The Importance of a Comfort Blanket for Children: A Crucial Psychological Comfort
The Shadow According to Carl Jung: How the Aspect of the Unconscious Functions in Children under 16
Unraveling Hikikomori: A Global Phenomenon of Social Withdrawal
Understanding Child Psychology Among the Navajo: Exploring Rituals, Shamanism, and Developmental Support
Empowering Mothers of All Ages: Embracing Body Positivity
Child Development: Are You Anxious About Autistic Risks?
Autism: Tools To Adapt Yourself To Your Child’s Emotions And Unexpressed Requests
Essential Items Every Mom Should Carry in Her Bag for Handling Minor Mishaps
Why You Should Take Your Kid to Charity Shops Even If You are Wealthy
Mindfulness with Your Kids
The Psychological Contents of Halloween